Curr Opin Chem Biol Special Issue on Biocatalysis, we edited with @CampopianoGroup is finally out! Many thanks to the authors that contributed.
https://www.sciencedirect.com/science/article/abs/pii/S1367593120300624
https://www.sciencedirect.com/journal/current-opinion-in-chemical-biology/vol/55/suppl/C
Includes our review – Harnessing and engineering amide bond forming ligases for the synthesis of amides
https://www.sciencedirect.com/science/article/abs/pii/S1367593119301486
Our latest paper just out @angew_chem – Engineering orthogonal methyltransferases to create alternative bioalkylation pathways. Well done Abi, Sarah et al.
https://doi.org/10.1002/anie.202004963
Very pleased to welcome Stanley Sowerby Thomas into our group. Stan is an Integrated Catalysis (@iCAT_CDT) PhD students who will be working on biocatalysis & chemocatalysis – telescoping routes to pharmaceuticals & other valuable products.
Delighted to welcome Katherine Robins to our group. Katherine obtained a PhD from the Victoria Univ of Wellington, New Zealand (@Dave_Ackerley) and was a PDRA at the Univ of Oxford. Eventually she will be working on engineering NRPS/PKS enzymes to deliver new antibiotics.
Farewell to CSC fellow Fanghua Wang, who has been doing excellent work in our lab engineering amide ligase enzymes which we hope to publish soon. Looking forward to visiting his lab at South China University of Technology during the next trip to China.
The Micklefield Lab’s latest paper has just been published in Nature Catalysis. The paper describes the discovery of a new biosynthetic pathway, with a highly unusual carboxylase enzyme (MloH), producing a structurally unique antibiotic malonomycin. The new findings might lead to the discovery of new antibiotics and may also provide new ways of making antibiotics which are urgently needed to combat emerging drug-resistant pathogens.
http://dx.doi.org/10.1038/s41929-018-0178-2
Jason Micklefield received a Visiting Professorship at the East China University of Science and Technology from Professor Yingping Zhuang the Dean of the Faculty of Bioengineering. He will use the position to consolidate collaborations with Professor Lixin Zhang’s group at ECUST and other laboratories in China.
Micklefield lab paper published online – Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase – Angewandte Chemie International Edition – Wiley Online Library https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201805060#.WztyyOva6SU.twitter …
