ERC Advanced Grant

Very happy our lab was awarded an ERC Advanced Grant. We will be looking to recruit several postdocs and PhDs soon ūüôā

https://erc.europa.eu/news-events/news/erc-2023-advanced-grants-results

https://www.manchester.ac.uk/discover/news/manchester-researchers-awarded-prestigious-funding-to-pursue-projects-that-could-lead-to-major-scientific-breakthroughs/

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RSC Horizon Prize: Rita and John Cornforth Award 2023

The Micklefield lab have been awarded the Royal Society of Chemistry’s 2023 Chemistry Biology Interface Horizon Prize: Rita and John Cornforth Award, in collaboration with GlaxoSmithKline, for successfully discovered new enzymes for sustainable synthesis.

They discovered and engineered enzymes and pathways to provide more sustainable and efficient routes to new and improved antimicrobials and other important therapeutic agents. Their work has the potential to help reduce problems of chemical waste and could lead to more affordable products, including medicines, to help combat antimicrobial resistance (AMR) and treat neglected diseases in the developing world.

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Annual summer party

Our lab had its annual summer party. Lots of beer & food as usual. It was great fun even when it started raining and we had to pack into the front room. Well done for all your excellent research. It is a privilege to work with you all!

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Directing Biosynthesis VI

We are having a great time at Directing Biosynthesis VI in Edinburgh presenting our recent research and enjoying some fantastic talks including an excellent lecture from our very own Wei li Thong

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Check out this short video

Want to see what a typical day in our lab looks like. Meet members of our group having fun, planning, executing and presenting their exciting research!

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Super pleased to Welcome four new postdocs to our lab:

Prof Dongxu Jia studied for his PhD at Jiangnan University in the field of fermentation engineering. He now works at the Zhejiang University of Technology as an associate professor and joins us as a visiting researcher with a CSC fellowship

Dr Guangcai Xu trained in biochemistry at Xi’an Jiaotong and the University of Liverpool. He worked in industrial biocatalysis at Suzhou before completing his PhD at the University of Groningen.

Dr Remi Zallot obtained his doctorate degree from Université de Bordeaux, held PDRA positions at University of Florida, University of Illinois at Urabana-Champaign and a Marie Curie Individual Fellowship at Swansea University

Dr Andreea Iorgu received her BEng in Chemical Engineering and MEng in Advanced Materials from Politehnica University of Bucharest before studying for a PhD in Biophysical Chemistry at the University of Manchester. She continued her research in Sam Hay’s group and joins the group as a PDRA.

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Warm welcome to two of the most recent PhD students to join our lab:

Aimee received her MChem degree from the University of Manchester. Continuing in Manchester, Aimee joined the iCAT CDT. She has previously completed project rotations with the Procter and the Bures group

Kehan studied for an MChem in Chemistry at the University of Manchester having undertaken internships at Nanjing Tech University, Suzhou university and Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences

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RSC Interdisciplinary Prize (2022).

Our group is very pleased that Jason won the RSC Interdisciplinary Prize (2022). “For innovative research spanning organic chemistry to molecular genetics, leading to the discovery, characterisation, and engineering of many¬†novel enzymes.‚ÄĚ

Many thanks to our very talented research group for their hard work, dedication and excellent research over the years, which has made this possible!

https://www.rsc.org/prizes-funding/prizes/2022-winners/professor-jason-micklefield/

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3rd Synthetic Biology of Natural Products Conference

Wei Li Thong, Katherine Robins & Mike Rowlinson had a great time presenting the labs most recent work at the 3rd Synthetic Biology of Natural Products Conference #SBNP22 in Mexico. Beautiful setting and a fantastic conference. Here they are having fun!

   

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Check out our labs work on Merging enzymes with chemocatalysis for amide bond synthesis

Merging enzymes with chemocatalysis for amide bond synthesis

Amides are one of the most fundamental chemical bonds in nature. In addition to proteins and other metabolites, many valuable synthetic products comprise amide bonds. Despite this, there is a need for more sustainable amide synthesis. Herein, we report an integrated next generation multi-catalytic system, merging nitrile hydratase enzymes with a Cu-catalysed N-arylation reaction in a single reaction vessel, for the construction of ubiquitous amide bonds. This synergistic one-pot combination of chemo- and biocatalysis provides an amide bond disconnection to precursors, that are orthogonal to those in classical amide synthesis, obviating the need for protecting groups and delivering amides in a manner unachievable using existing catalytic regimes. Our integrated approach also affords broad scope, very high (molar) substrate loading, and has excellent functional group tolerance, telescoping routes to natural product derivatives, drug molecules, and challenging chiral amides under environmentally friendly conditions at scale.

For more background see:
https://go.nature.com/3FCmSxf

And for news reports see:
Greener amide bonds in Nature Chem Biol:  https://doi.org/10.1038/s41589-022-00988-7
Collaborative catalysis in Nature Reviews Chemistry : https://www.nature.com/articles/s41570-022-00369-7
Enzyme-and-copper combo builds amide bonds via @cenmag: https://cen.acs.org/synthesis/Enzyme-copper-combo-builds-amide/100/i4

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