Our labs latest paper is in Nature.

The paper is about amide ligase enzymes – from bacterial phytotoxins, natural product biosynthesis, enzyme structure & engineering, to biocatalysis & new routes to drugs for COVID19 etc.

https://www.nature.com/articles/s41586-021-03447-w
https://rdcu.be/ckWgF

For more information see the full news story here.

For more technical details behind the paper see this blog post.

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Micklefield lab paper latest paper in Nature Catalysis

This paper describes a new way of integrating engineered enzymes and cells, with metal catalysis in a single process, telescoping more sustainable routes to drugs and other targets.

https://www.nature.com/articles/s41929-021-00603-3
https://rdcu.be/ckYsL

For more information see the full news story here.

For more technical details behind the paper see this blog post.

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Super happy to welcome our new PhDs for 2020/21 – Jess, Joe, Eloise & Stuart

A belated, but nonetheless, very warm welcome to our new PhD students for the academic year 2020/21.

Pictured from left to right  Jess, Joe & Eloise. 

Jessica Logue received her MChem from the University of Lancaster and is now working on discovery, characterisation and engineering new enzymes for more sustainable synthesis.

Joseph Thompson completed his MChem degree at the University of Nottingham and will be working on new routes to nucleic acid therapeutics.

Eloise O’ Connor was awarded BSc in Biochemistry from Imperial College. Eloise will be developing new synthetic biology approaches for re-assembling biosynthetic pathways for heterologous expression in new yeast strains in collaboration with Prof. Patrick Cai.

 

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Delighted to welcome Dr Puja Saha

Delighted to welcome Dr Puja Saha to our group. Puja won a prestigious Royal Society Newton Fellowship to work in our lab.

Previously Puja was IACS Senior Research Fellow & CSIR Junior Research Fellow with Prof. Jyotirmayee Dash at the Indian Association for the Cultivation of Science, Jadavpur, Kolkata, India. Puja obtained a Ph.D. in Biochemistry, from the University of Calcutta, studying I-motif DNA secondary structure in cancer therapeutics. She also received M.Sc.and B. Sc degrees in Microbiology from the University of Calcutta. Puja will be working on developing new enzymatic cascades to deliver new antibiotics urgently required to combat AMR and treat neglected diseases.

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Special Issue on Biocatalysis

Curr Opin Chem Biol Special Issue on Biocatalysis, we edited with @CampopianoGroup is finally out! Many thanks to the authors that contributed.

https://www.sciencedirect.com/science/article/abs/pii/S1367593120300624

https://www.sciencedirect.com/journal/current-opinion-in-chemical-biology/vol/55/suppl/C

Includes our review – Harnessing and engineering amide bond forming ligases for the synthesis of amides

https://www.sciencedirect.com/science/article/abs/pii/S1367593119301486

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Orthogonal methyltransferase paper in Angewandte

Our latest paper just out @angew_chem – Engineering orthogonal methyltransferases to create alternative bioalkylation pathways. Well done Abi, Sarah et al.

https://doi.org/10.1002/anie.202004963

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Welcome Stanley

Very pleased to welcome Stanley Sowerby Thomas into our group. Stan is an Integrated Catalysis (@iCAT_CDTPhD students who will be working on biocatalysis & chemocatalysis – telescoping routes to pharmaceuticals & other valuable products.

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Delighted to welcome Katherine Robins.

Delighted to welcome Katherine Robins to our group. Katherine obtained a PhD from the Victoria Univ of Wellington, New Zealand (@Dave_Ackerley) and was a PDRA at the Univ of Oxford. Eventually she will be working on engineering NRPS/PKS enzymes to deliver new antibiotics.

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Farewell Fangua

Farewell to CSC fellow Fanghua Wang, who has been doing excellent work in our lab engineering amide ligase enzymes which we hope to publish soon. Looking forward to visiting his lab at South China University of Technology during the next trip to China.

 

 

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Our lab had a well deserved summer break – Go karting, team bonding & partying with lots of beer, pizza & sunshine.

garden

gokart

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