Category Archives: Uncategorized

Our latest paper just out @angew_chem – Engineering orthogonal methyltransferases to create alternative bioalkylation pathways. Well done Abi, Sarah et al. https://doi.org/10.1002/anie.202004963

Very pleased to welcome Stanley Sowerby Thomas into our group. Stan is an Integrated Catalysis (@iCAT_CDT) PhD students who will be working on biocatalysis & chemocatalysis – telescoping routes to pharmaceuticals & other valuable products.

Delighted to welcome Katherine Robins to our group. Katherine obtained a PhD from the Victoria Univ of Wellington, New Zealand (@Dave_Ackerley) and was a PDRA at the Univ of Oxford. Eventually she will be working on engineering NRPS/PKS enzymes to … Continue reading →

Farewell to CSC fellow Fanghua Wang, who has been doing excellent work in our lab engineering amide ligase enzymes which we hope to publish soon. Looking forward to visiting his lab at South China University of Technology during the next … Continue reading →

The Micklefield Lab’s latest paper has just been published in Nature Catalysis. The paper describes the discovery of a new biosynthetic pathway, with a highly unusual carboxylase enzyme (MloH), producing a structurally unique antibiotic malonomycin. The new findings might lead to the discovery … Continue reading →

Jason Micklefield received a Visiting Professorship at the East China University of Science and Technology from Professor Yingping Zhuang the Dean of the Faculty of Bioengineering. He will use the position to consolidate collaborations with Professor Lixin Zhang’s group at ECUST … Continue reading →

We are pleased to welcome Dr Imtiaz Khan into the Micklefield Lab. Imtiaz will be working on a new BBSRC funded project, integrating enzymes with chemocatalysts to open up new reaction pathways, following on from early work in the lab … Continue reading →

Micklefield lab paper published online – Structure and Biocatalytic Scope of Coclaurine N‐Methyltransferase – Angewandte Chemie International Edition – Wiley Online Library https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201805060#.WztyyOva6SU.twitter …

De novo Biosynthesis of “Non‐Natural” Thaxtomin Phytotoxins – Winn – 2018 – Angewandte Chemie International Edition – Wiley Online Library https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201801525#.WzJHxI2Z8OY.twitter