Category Archives: Uncategorized

Our group is very pleased that Jason won the RSC Interdisciplinary Prize (2022). “For innovative research spanning organic chemistry to molecular genetics, leading to the discovery, characterisation, and engineering of many novel enzymes.” Many thanks to our very talented research group … Continue reading →

Wei Li Thong, Katherine Robins & Mike Rowlinson had a great time presenting the labs most recent work at the 3rd Synthetic Biology of Natural Products Conference #SBNP22 in Mexico. Beautiful setting and a fantastic conference. Here they are having … Continue reading →

Merging enzymes with chemocatalysis for amide bond synthesis Amides are one of the most fundamental chemical bonds in nature. In addition to proteins and other metabolites, many valuable synthetic products comprise amide bonds. Despite this, there is a need for more sustainable … Continue reading →

Photos from top left: Stuart, Isobel, Sebastian, Sydney, Luke Stuart Angiolini completed his MChem degree at Heriot-Watt University in 2020. During his degree, he completed a yearlong industrial placement with Fiberlean Technologies in Cornwall, working on development of paper and … Continue reading →

Gene editing enables rapid engineering of complex antibiotic assembly lines Our most recent paper describes an entirely new route to complex antibiotics exploiting gene editing to re-programme pathways to future medicines urgently required to combat antimicrobial resistance, treat neglected diseases … Continue reading →

The paper is about amide ligase enzymes – from bacterial phytotoxins, natural product biosynthesis, enzyme structure & engineering, to biocatalysis & new routes to drugs for COVID19 etc.https://www.nature.com/articles/s41586-021-03447-whttps://rdcu.be/ckWgF For more information see the full news story here. For more technical … Continue reading →

This paper describes a new way of integrating engineered enzymes and cells, with metal catalysis in a single process, telescoping more sustainable routes to drugs and other targets.https://www.nature.com/articles/s41929-021-00603-3https://rdcu.be/ckYsL For more information see the full news story here. For more technical details … Continue reading →

A belated, but nonetheless, very warm welcome to our new PhD students for the academic year 2020/21. Pictured from left to right  Jess, Joe & Eloise.  Jessica Logue received her MChem from the University of Lancaster and is now working on … Continue reading →

Delighted to welcome Dr Puja Saha to our group. Puja won a prestigious Royal Society Newton Fellowship to work in our lab. Previously Puja was IACS Senior Research Fellow & CSIR Junior Research Fellow with Prof. Jyotirmayee Dash at the … Continue reading →

Curr Opin Chem Biol Special Issue on Biocatalysis, we edited with @CampopianoGroup is finally out! Many thanks to the authors that contributed. https://www.sciencedirect.com/science/article/abs/pii/S1367593120300624 https://www.sciencedirect.com/journal/current-opinion-in-chemical-biology/vol/55/suppl/C Includes our review – Harnessing and engineering amide bond forming ligases for the synthesis of amides https://www.sciencedirect.com/science/article/abs/pii/S1367593119301486