Dr. Matthew Styles

Matthew Styles obtained his MChem in 2009 from Durham University, carrying out his final year project in the Drug Metabolism Pharmacokinetics (DMPK) department at AstraZeneca where he worked on the absolute quantification of proteins in complex biological matrices.  He currently works on several projects in the Micklefield group, with interests in biocatalysis and biosynthesis of non-ribosomal peptide antibiotics.  Matt has a great deal of experience in analytical chemistry, and brings expertise in mass spectrometry, HPLC and solid phase extraction techniques into the group.


Engineered Biosynthesis of Enduracidin Lipoglycopeptide Antibiotics using the Ramoplanin Mannosyltransferase Ram29. M.-C. Wu, M.Q. Styles, L. Nunns, B.J.C. Law, J. Micklefield 2015 161: 1338-1347 DOI:10.1099/mic.0.000095

Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity. J. Thirlway, R. Lewis, L. Nunns, M. Al Nakeeb, M. Styles, A.-W. Struck, C.P. Smith and J. Micklefield Angew. Chem. Int. Ed 2012, 51, 7181-7184 (http://dx.doi.org/10.1002/anie.201202043)

Conference contributions, other (presenting author is underlined)

M. Styles, M.-C. Wu, L. Nunns, B. Law, J. Micklefield, “Combinatorial Biosynthesis of Non-Ribosomal Peptide Antibiotics” 2nd RSC Symposium on Chemical Biology for Drug Discovery, 2012 March 20-21, Alderley Park Conference Centre, Cheshire, UK