Dr. T.H. Samuel Tan


Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties. R. Worthington, A. O’Rourke, J. Morral, T.H.S. Tan and J. Micklefield Org. Biomol. Chem., 2007, 5, 249-259. (http://dx.doi.org/10.1039/b613386j)

Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties. T.H.S. Tan, R. Worthington, A. O’Rourke, J. Morral, R.G. Pritchard and J. Micklefield Org. Biomol. Chem., 2007, 5, 239-248. (http://dx.doi.org/10.1039/b613384n)

These two OBC papers were highlighted on the front cover: “Pyrrolidine amide oligonucleotide mimics (POM): Chemical biology solutions from zebrafish developmental biology through to high throughput DNA sequencing.”

Effects of stereospecific backbone methylation on the DNA/RNA binding properties of pyrrolidine-amide oligonucleotide mimics (cPOM). A. Khan, T.H.S. Tan and J. Micklefield Chem. Commun. 2006, 1436-1438. (http://dx.doi.org/10.1039/b518171b)

Superior nucleic acid binding properties of adeninyl pyrrolidine-amide oligonucleotide mimics (POM). T.H.S. Tan, D.T. Hickman, J. Morral, I.G. Beadham and J. Micklefield Chem. Commun. 2004, 516-517. (http://dx.doi.org/10.1039/b315768g)

Design, synthesis, conformational analysis and nucleic acic hybridisation properties of thymidyl pyrrolidine-amid oligonuceotide mimics (POM). D.T. Hickman, T.H.S. Tan, J. Morral, P.M. King, M.A. Cooper and J. Micklefield Org. Biomol. Chem. 2003, 1, 3277-3292. (http://dx.doi.org/10.1039/b306156f)

Conference contributions, refereed:

A.I. Khan, T.H.S. Tan, J. Morral-Cardoner and J. Micklefield “Synthesis and DNA/RNA binding properties of conformationally restricted pyrrolidine-amide oligonucleotide mimics (POM).” Abstr. Pap. Am. Chem. Soc. 2003, 226, ORGN-510.

Conference contributions, other (presenting author is underlined):

A.I. Khan, D.T. Hickman, T.H.S. Tan and J. Micklefield. “Synthesis and DNA/RNA Binding properties of Second-generation Pyrrolidine amide Oligonucleotide Mimic (POM).” RSC Postgraduate Symposium on Organic and Medicinal Chemistry, Cambridge University, 9 Dec 2002. (poster)

T.H.S. Tan, J. Morral-Cardoner, D.T. Hickman and J. Micklefield. “Solid phase synthesis and biophysical studies of pyrrolidine-amide oligonucleotide mimics (POM).” IUPAC 6th International Symposium of Bio-organic Chemistry, Toronto, Canada, Aug 11-14, 2002, pp. 75.

T.H.S. Tan, J. Micklefield and D.T. Hickman. “Pyrrolidine-Amide Oligonucleotide Mimics (POM).” RSC Bio-organic Group Postgraduate Symposium, John Innes Centre, Norwich, 17 Dec 2001. Samuel Tan won the Prize for best poster.

T.H.S. Tan, J. Micklefield and D.T. Hickman. “Pyrrolidine-amide oligonucleotide mimics (POM): Synthesis and biophysical studies.” NACON-V International Conference on Nucleic Acid Recognition, University of Sheffield, 8-12 Apr 2001. (poster).