Dr. Adam P. O’Rourke


Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties. R. Worthington, A. O’Rourke, J. Morral, T.H.S. Tan and J. Micklefield Org. Biomol. Chem., 2007, 5, 249-259. (http://dx.doi.org/10.1039/b613386j)

Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties. T.H.S. Tan, R. Worthington, A. O’Rourke, J. Morral, R.G. Pritchard and J. Micklefield Org. Biomol. Chem., 2007, 5, 239-248. (http://dx.doi.org/10.1039/b613384n)

These two OBC papers were highlighted on the front cover: “Pyrrolidine amide oligonucleotide mimics (POM): Chemical biology solutions from zebrafish developmental biology through to high throughput DNA sequencing.”

Conference contributions, refereed:

A.P. O’Rourke, R.J. Worthington, J. Morral and J. Micklefield “Synthesis and UV hybridization studies of mixed-sequence pyrrolidine-amide oligonucleotide mimics (POM).” Abstr. Pap. Am. Chem. Soc. 2005, 230, ORGN-605.

Conference contributions, other (presenting author is underlined)

R. Worthington, N. Bell, A. O’Rourke, J. Micklefield “Redesigning nature’s genetic material: pyrrolidine amide oligonucleotide mimics” RSC Bio-organic Chemistry Annual Meeting. MIB Manchester, 18 Dec 2006. (Poster)

R. Worthington, A. O’Rourke, J. Micklefield “Synthesis and DNA/RNA binding properties of mixed sequence pyrrolidine amide oligonucleotide mimics” RSC Nucleic Acids Forum, MIB Manchester 7 July 2006. (Poster).