Dr. Matthew Borg


Engineered biosynthesis of nonribosomal lipopeptide antibiotics with modified fatty acid side chains. A. Powell, M. Borg, B. Amir-Heidari, J.M. Neary, J. Thirlway, B. Wilkinson, C.P. Smith and J. Micklefield J. Am. Chem. Soc. 2007, 129, 15182-15191. Articles based on this paper were published in the Daily Express, Chemistry & Industry, Manchester Evening News see below. (http://dx.doi.org/10.1021/ja074331o)

Active-site modifications of adenylation domains leads to hydrolysis of upstream nonribosomal peptidyl thioester intermediates. G.C. Uguru, C. Milne, M. Borg, F. Flett, C.P. Smith and J. Micklefield J. Am. chem. Soc. 2004, 126, 5032-5033. (http://dx.doi.org/10.1021/ja048778y)

Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from Streptomyces coelicolor. Z. Hojati, C. Milne, L. Gordon, M. Borg, F. Flett, B. Wilkinson, P. J. Sidebottom, B.A.M. Rudd, M.A. Hayes, C.P. Smith and J. Micklefield Chemistry & Biology 2002, 9, 1175-1187. (http://dx.doi.org/10.1016/s1074-5521(02)00252-1). Featured as the lead article and was illustrated on the fron cover “Chemobiosynthesis leads to new lipopeptide antibiotics”. This paper was also reviewed “New compounds by combining modern genomics and old-fashioned mutasynthesis” by Wohlleben, W.; Pelzer, S. Chemistry & Biology 2002, 9, 1163

Conference contributions, other (presenting author is underlined):

M. Borg, J. Micklefield, C.P. Smith. “The fatty acid biosynthesis Operon in the CDA cluster” Abstracts of the 9th International Symposium on the genetics of industrial microorganisms (GIM), Gyongju, Korea, 1-5 July, 2002, pp. 88.

J. Micklefield, A.E. Hayes, Z. H. Najafabadi, G.C. Uguru, J.M. Neary, C. Milne, L. Gordon, J. Jim, M. Borg, F. Flett and C.P. Smith. “CDA biosynthesis: towards the engineered biosynthesis of novel lipopeptide antibiotics.” BBSRC Workshop on Natural Products Biology, University of Warwick, 21-22 May 2001 (poster)

J. Micklefield, A.E. Hayes, Z. H. ajafabadi, G.C. Uguru, J.M. Neary, C. Milne, L. Gordon, J. Jim, M. Borg, F. Flett and C.P. Smith. “Characterisation of the nonribosomal peptide synthetases and other key enzymes involved in CDA biosynthesis: Towards the engineered biosynthesis of novel lipopeptide antibiotics.” Conference on Streptomyces, University of Warwick, Feb 2001. (Poster).