Professor Roberta Worthington


Biophysical and Cellular Uptake Properties of Mixed Sequence Pyrrolidine-amide Oligonucleotide Mimics. R. Worthington and J. Micklefield Chem. Eur. J., 2011, 17, 14429-14441 (

RNA selective cross-pairing of backbone extended pyrrolidine-amide oligonucleotide mimics (bePOMs). R. Worthington, N. Bell and J. Micklefield Org. Biomol. Chem. 2008, 6, 92-103. (

Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA/RNA binding properties. R. Worthington, A. O’Rourke, J. Morral, T.H.S. Tan and J. Micklefield Org. Biomol. Chem., 2007, 5, 249-259. (

Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA/RNA binding properties. T.H.S. Tan, R. Worthington, A. O’Rourke, J. Morral, R.G. Pritchard and J. Micklefield Org. Biomol. Chem., 2007, 5, 239-248. (

These two OBC papers were highlighted on the front cover: “Pyrrolidine amide oligonucleotide mimics (POM): Chemical biology solutions from zebrafish developmental biology through to high throughput DNA sequencing.”

Conference contributions, refereed:

Bell, Neil M.; Worthington, Roberta J.; Micklefield, Jason. Nucleic acid redesign, recognition and transcription: The pyrrolidine-amide oligonucleotide mimics. Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (2008), BIOL-171

Bell, Neil M.; Worthington, Roberta J.; Micklefield, Jason. Nucleic acid redesign and recognition: The pyrrolidine-amide oligonucleotide mimics (POMs). Collection Symposium Series (2008), 10 (Chemistry of Nucleic Acid Components), 206-209.

A.P. O’Rourke, R.J. Worthington, J. Morral and J. Micklefield “Synthesis and UV hybridization studies of mixed-sequence pyrrolidine-amide oligonucleotide mimics (POM).” Abstr. Pap. Am. Chem. Soc. 2005, 230, ORGN-605.

Conference contributions, other (presenting author is underlined)

R. WongR. Worthington, J. Micklefield “Synthesis and biophysical studies of pyrrolidine-amide oligonucleotide mimic (POM) and non-enzymatic transcription of nucleic acids.” EPSRC Synthetic Studentship Review, Jury’s Inn Birmingham, 27 June 2007. (Poster)

R. Worthington, N. Bell, A. O’Rourke, J. Micklefield “Redesigning nature’s genetic material: pyrrolidine amide oligonucleotide mimics” RSC Bio-organic Chemistry Annual Meeting. MIB Manchester, 18 Dec 2006. (Poster)

R. Worthington, A. O’Rourke, J. Micklefield “Synthesis and DNA/RNA binding properties of mixed sequence pyrrolidine amide oligonucleotide mimics” RSC Nucleic Acids Forum, MIB Manchester 7 July 2006. (Poster).