Publications:
Superior nucleic acid binding properties of adeninyl pyrrolidine-amide oligonucleotide mimics (POM). T.H.S. Tan, D.T. Hickman, J. Morral, I.G. Beadham and J. Micklefield Chem. Commun. 2004, 516-517. (http://dx.doi.org/10.1039/b315768g)
Design, synthesis, conformational analysis and nucleic acic hybridisation properties of thymidyl pyrrolidine-amid oligonuceotide mimics (POM). D.T. Hickman, T.H.S. Tan, J. Morral, P.M. King, M.A. Cooper and J. Micklefield Org. Biomol. Chem. 2003, 1, 3277-3292. (http://dx.doi.org/10.1039/b306156f)
Synthesis and nucleic-acid-binding properties of sulfamide and 3-N-sulfamate modified DNA. K.J. Fettes, N. Howard, D.T. Hickman, S.A. Adah, M.R. Player, P.F. Torrence and J. Micklefield J. Chem. Soc., Perkin Trans. 1 2002, 485-495. (http://dx.doi.org/10.1039/b110603c)
Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM). D.T. Hickman, P.M. King, J.M. Slater, M.A.Cooper and J. Micklefield Nucleosides, Nucleotides & Nucleic Acids 2001, 20, 1169-1172. (http://dx.doi.org/10.1081/NCN-100002512)
Unusual RNA & DNA binding properties of a novel pyrrolidine-amide oligonucleotide mimics (POM). D.T. Hickman, P.M. King, M.A. cooper, J.M. Slater and J. Micklefield Chem.Commun. 2000, 2251-2252. (http://dx.doi.org/10.1039/b006903p)
Replacement of the phosphodiester linkage in DNA with sulfamide and 3′-N-sulfamate groups. K. J. Fettes, N. Howard, D.T. Hickman, S.A. Adadh, M.R. Player, P.F. Torrence and J. Micklefield Chem. Commun., 2000, 765-766. (http://dx.doi.org/10.1039/b001586p)
Conference contributions, other (presenting author is underlined):
A.I. Khan, D.T. Hickman, T.H.S. Tan and J. Micklefield. “Synthesis and DNA/RNA Binding properties of Second-generation Pyrrolidine amide Oligonucleotide Mimic (POM).” RSC Postgraduate Symposium on Organic and Medicinal Chemistry, Cambridge University, 9 Dec 2002. (poster)
T.H.S. Tan, J. Morral-Cardoner, D.T. Hickman and J. Micklefield. “Solid phase synthesis and biophysical studies of pyrrolidine-amide oligonucleotide mimics (POM).” IUPAC 6th International Symposium of Bio-organic Chemistry, Toronto, Canada, Aug 11-14, 2002, pp. 75.
T.H.S. Tan, J. Micklefield and D.T. Hickman. “Pyrrolidine-Amide Oligonucleotide Mimics (POM).” RSC Bio-organic Group Postgraduate Symposium, John Innes Centre, Norwich, 17 Dec 2001. Samuel Tan won the Prize for best poster.
T.H.S. Tan, J. Micklefield and D.T. Hickman. “Pyrrolidine-amide oligonucleotide mimics (POM): Synthesis and biophysical studies.” NACON-V International Conference on Nucleic Acid Recognition, University of Sheffield, 8-12 Apr 2001. (poster).
D.T. Hickman, P.M. King, J.M. slater, M.A. Cooper and J. Micklefield. “Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM).” XIV International Roundtable: Nucleosides, Nucleotides and Their Biological Applications, San Francisco, USA, Sept 2000. (poster).
D.T. Hickman, J. Micklefield and J.M. Slater. “Postively charged pyrrolidine polyamide nucleic acid analogues.” Royal Society of Chemistry 1999 Annual Conference, Heriot-Watt Univ., 1999. (poster).