Dr. Joanne M. Neary

Publications:

Engineered biosynthesis of nonribosomal lipopeptide antibiotics with modified fatty acid side chains. A. Powell, M. Borg, B. Amir-Heidari, J.M. Neary, J. Thirlway, B. Wilkinson, C.P. Smith and J. Micklefield J. Am. Chem. Soc. 2007, 129, 15182-15191. Articles based on this paper were published in the Daily Express, Chemistry & Industry, Manchester Evening News see below. (http://dx.doi.org/10.1021/ja074331o)

An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium dependent lipopeptide antibiotics. J. Neary, A. Powell, L. Gordon, C. Milne, F. Flett, B. Wilkinson, C.P. Smith and J. Micklefield Microbiology 2007, 153, 768-776. (http://dx.doi.org/10.1099/mic.0.2006/002725-0)

Conference contributions, other (presenting author is underlined):

J.M. Neary, C. Milne, J. Micklefield, C.P. Smith “Characterisation and manipulation of the non-ribosomal peptide synthetase enzymes involved in CDA biosynthesis.” Abstracts of the 9th International Symposium on the genetics of industrial microorganisms (GIM), Gyongju, Korea, 1-5 July 2002 pp.96.

J. Micklefield, A.E. Hayes, Z. H. Najafabadi, G.C. Uguru, J.M. Neary, C. Milne, L. Gordon, J. Jim, M. Borg, F. Flett and C.P. Smith. “CDA biosynthesis: towards the engineered biosynthesis of novel lipopeptide antibiotics.” BBSRC Workshop on Natural Products Biology, University of Warwick, 21-22 May 2001 (poster)

J. Micklefield, A.E. Hayes, Z. H. ajafabadi, G.C. Uguru, J.M. Neary, C. Milne, L. Gordon, J. Jim, M. Borg, F. Flett and C.P. Smith. “Characterisation of the nonribosomal peptide synthetases and other key enzymes involved in CDA biosynthesis: Towards the engineered biosynthesis of novel lipopeptide antibiotics.” Conference on Streptomyces, University of Warwick, Feb 2001. (Poster).