Publications:
Engineered biosynthesis of nonribosomal lipopeptide antibiotics with modified fatty acid side chains. A. Powell, M. Borg, B. Amir-Heidari, J.M. Neary, J. Thirlway, B. Wilkinson, C.P. Smith and J. Micklefield J. Am. Chem. Soc. 2007, 129, 15182-15191. Articles based on this paper were published in the Daily Express, Chemistry & Industry, Manchester Evening News see below. (http://dx.doi.org/10.1021/ja074331o)
Precursor-directed biosynthesis of nonribosomal lipopeptides with modified glutamate residues. A. Powell, M. Al Nakeeb, B. Wilkinson and J. Micklefield Chem. Commun. 2007, 2683-2685. Highlighted on the front cover. (http://dx.doi.org/10.1039/b706224a)
An asparagine oxygenase (AsnO) and a 3-hydroxyasparaginyl phosphotransferase (HasP) are involved in the biosynthesis of calcium dependent lipopeptide antibiotics. J. Neary, A. Powell, L. Gordon, C. Milne, F. Flett, B. Wilkinson, C.P. Smith and J. Micklefield Microbiology 2007, 153, 768-776. (http://dx.doi.org/10.1099/mic.0.2006/002725-0)
Biosynthesis of the (2S,3R)-3-methyl glutamate residue of nonribosomal lipopeptides. C. Milne, A. Powell, J. Jim, M. Al Nakeeb, C.P. Smith and J. Micklefield J. Am. Chem. Soc. 2006, 128, 11250-11259. (http://dx.doi.org/10.1021/ja062960c)