Eileen Brandenburger graduated in 2017 with a PhD in Biocatalysis from The University of Manchester. She obtained a 1st class M.Sc. in Chemistry from the Justus-Liebig-University in Germany in 2013. During the degree, she gained a diverse chemistry knowledge with a focus on biological inorganic chemistry under the supervision of Prof. Siegfried Schindler. Eileen’s master’s project dealing with methane monooxygenase model systems was carried out under the supervision of Prof. Vickie McKee at Loughborough University and funded by an ERASMUS scholarship.
Eileen joined the Micklefield group in November 2013 as a postgraduate researcher working in the field of biocatalysis. She is currently developing new halogenases for the regioselective installation of halogens on electron-rich substrates. Her research interests include enzyme engineering, enzymology, biosynthetic pathway reconstruction in E.Coli and natural product synthesis. Techniques applied on a day to day basis involve the chemical synthesis of substrates and standards, heterologous gene expression and protein purification, HPLC, NMR, LCMS and MS.
Eileen is a native German speaker and fluent in English. In her spare time, you can find her at the ballet either performing herself or watching in the audience.
Publications
Development of Halogenase Enzymes for Use in Synthesis J. Latham, E. Brandenburger, S. A. Shepherd, B. R. K. Menon and J.Micklefield Chem. Rev 2018, 118, 232-269; (http://dx.doi.org/10.1021/acs.chemrev.7b00032)
RadH: A Versatile Halogenase for Integration into Synthetic Pathways. B. R. K. Menon, E. Brandenburger, H. H. Sharif, U. Klemstein, M. F. Greaney, and J. Micklefield Angew. Chem. Int. Ed. 2017 in press (http://dx.doi.org/10.1002/anie.201706342)
Development of Halogenase Enzymes for use in Synthesis. Jonathan Latham, Eileen Brandenburger, Sarah A. Shepherd, Binuraj R. K. Menon and Jason Micklefield. American Chemical Society. 2017, (DOI: 10.1021/acs.chemrev.7b00032)
Structure and Biocatalytic Scope of Thermophillic Flavin-Dependent Halogenase and Flavin Reductase Enzymes B. R. K. Menon, J. Latham, M. S. Dunstan, E. Brandenburger, U. Klemstein, S. A. Shepherd, C. Karthikeyan, M. F. Greaney, D. Leys and J. Micklefield* Org. Biomol. Chem. 2016, 14, 9354–9361. (http://dx.doi.org/10.1039/C6OB01861K)
Selected conference contributions:
Brandenburger, E.; Menon, B. R. K.; Micklefield, J. Development of Halogenase Enzymes as novel Biocatalysts, Gordon Research Conference: Biocatalysis 2016, University of New England, Biddeford, ME, USA. (Research talk)
Brandenburger, E. Menon, B. R. K.; Micklefield, J. Halogenase Enzymes for Regioselective Aromatic Halogenation, 2014, Hamburg University of Technology, Hamburg, GER. (Poster presentation)
Brandenburger E., McKee, V.; Schindler, S. Structural Investigation of Methane Monooxygenase Model Systems, RSC Coordination Chemistry Discussion Group 2013, Imperial College, London, UK. (Poster presentation)