{"id":1575,"date":"2022-06-13T12:32:02","date_gmt":"2022-06-13T11:32:02","guid":{"rendered":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?p=1575"},"modified":"2022-06-13T12:32:02","modified_gmt":"2022-06-13T11:32:02","slug":"check-out-our-labs-work-on-merging-enzymes-with-chemocatalysis-for-amide-bond-synthesis","status":"publish","type":"post","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?p=1575","title":{"rendered":"Check out our labs work on Merging enzymes with chemocatalysis for amide bond synthesis"},"content":{"rendered":"<p><em><strong><a href=\"https:\/\/doi.org\/10.1038\/s41467-022-28005-4\">Merging enzymes with chemocatalysis for amide bond synthesis<\/a><\/strong><\/em><\/p>\n<p><a href=\"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/wp-content\/uploads\/2022\/06\/amides.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-1576\" src=\"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/wp-content\/uploads\/2022\/06\/amides.png\" alt=\"\" width=\"587\" height=\"480\" srcset=\"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/wp-content\/uploads\/2022\/06\/amides.png 587w, https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/wp-content\/uploads\/2022\/06\/amides-300x245.png 300w\" sizes=\"auto, (max-width: 587px) 100vw, 587px\" \/><\/a><\/p>\n<p>Amides are one of the most fundamental chemical bonds in nature. In addition to proteins and other metabolites, many valuable synthetic products comprise\u00a0amide bonds. Despite this, there is a need for more\u00a0sustainable amide synthesis. Herein, we report an integrated next generation multi-catalytic system, merging\u00a0nitrile hydratase enzymes with a Cu-catalysed N-arylation reaction in a single reaction vessel, for\u00a0the construction of ubiquitous amide bonds. This synergistic\u00a0one-pot combination of chemo- and biocatalysis provides an amide bond disconnection to precursors, that are orthogonal to those in classical amide\u00a0synthesis,\u00a0obviating the need for protecting groups and delivering amides in a manner unachievable using existing catalytic regimes. Our integrated approach also affords\u00a0broad scope, very high (molar)\u00a0substrate loading, and has excellent functional group tolerance, telescoping routes to natural product derivatives, drug molecules,\u00a0and challenging chiral amides under environmentally friendly conditions at\u00a0scale.<\/p>\n<p>For more background see:<br \/>\n<a href=\"https:\/\/go.nature.com\/3FCmSxf\">https:\/\/go.nature.com\/3FCmSxf<\/a><\/p>\n<p>And for news reports see:<br \/>\nGreener amide bonds in Nature Chem Biol: \u00a0<a href=\"https:\/\/doi.org\/10.1038\/s41589-022-00988-7\">https:\/\/doi.org\/10.1038\/s41589-022-00988-7<\/a><br \/>\nCollaborative catalysis in Nature Reviews Chemistry : <a href=\"https:\/\/www.nature.com\/articles\/s41570-022-00369-7\">https:\/\/www.nature.com\/articles\/s41570-022-00369-7<\/a><br \/>\nEnzyme-and-copper combo builds amide bonds via\u00a0@cenmag:\u00a0<a href=\"https:\/\/cen.acs.org\/synthesis\/Enzyme-copper-combo-builds-amide\/100\/i4\">https:\/\/cen.acs.org\/synthesis\/Enzyme-copper-combo-builds-amide\/100\/i4<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Merging enzymes with chemocatalysis for amide bond synthesis Amides are one of the most fundamental chemical bonds in nature. In addition to proteins and other metabolites, many valuable synthetic products comprise\u00a0amide bonds. Despite this, there is a need for more\u00a0sustainable &hellip; <a href=\"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?p=1575\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1575","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/posts\/1575","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1575"}],"version-history":[{"count":1,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/posts\/1575\/revisions"}],"predecessor-version":[{"id":1577,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/posts\/1575\/revisions\/1577"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1575"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1575"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1575"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}