{"id":57,"date":"2012-08-22T20:50:02","date_gmt":"2012-08-22T19:50:02","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=57"},"modified":"2025-01-07T16:37:00","modified_gmt":"2025-01-07T16:37:00","slug":"personal-details","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/","title":{"rendered":"Jason Micklefield"},"content":{"rendered":"

Professor of Chemical Biology<\/span><\/strong><\/h3>\n

Solvitur ambulando<\/em><\/p>\n

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Imperial College London\u00a0<\/strong>
\nDepartment of Chemistry
\nMolecular Sciences Research Hub
\nWhite City Campus, 82 Wood Lane, London W12 0BZ<\/p>\n

Email: <\/strong>j.micklefield@imperial.ac.uk<\/p>\n

Twitter: <\/strong>@Micklefield_Lab<\/a><\/p>\n

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Marie Sklodowska-Curie Actions (MSCA) Postdoctoral Fellowships<\/strong><\/p>\n

Our lab hosted several successful Marie Curie Fellows in the last few years. Email us if you are interested in research at the chemistry-biology interface & want to apply for a MCSA Fellowship<\/p>\n

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Biography<\/strong><\/p>\n

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Jason Micklefield is Professor of Chemical Biology within the Department of Chemistry at Imperial College London. \u00a0He graduated from the University of Cambridge<\/a>\u00a0in 1993 with a PhD in Chemistry, working with Prof Sir Alan R. Battersby FRS to complete the first total synthesis of haem d1. He then moved to the\u00a0University of Washington<\/a>, USA, as a NATO postdoctoral fellow investigating various biosynthetic pathways and enzyme mechanisms with Prof Heinz G. Floss. In 1995 he began his independent research career as a Lecturer in Organic Chemistry at Birkbeck College<\/a>,\u00a0University of London.<\/a> He moved \u00a0to University of Manchester in 1998, where he was Professor in Department of Chemistry. In 2024 he moved to his current position at Imperial.<\/p>\n

Current Research<\/strong><\/p>\n<\/div>\n<\/div>\n

The Micklefield Lab develop more sustainable bio-inspired ways to build molecules<\/strong>. Our lab has an eclectic philosophy and is highly interdisciplinary, engaged in\u00a0Chemical and\u00a0Synthetic Biology\u00a0research tackling diverse challenges at the Chemistry-Biology interface. We exploit techniques and knowledge from organic chemistry and enzymology through to molecular microbiology and genetics to develop sustainable routes to target molecules for therapeutic and other applications.\u00a0The main research themes include: 1) Biosynthesis and biosynthetic pathway engineering<\/a> providing novel bioactive natural products particularly new antibiotics to combat antimicrobial resistance (AMR) and treat neglected diseases; 2)<\/a> Biocatalysis & integrated catalysis<\/a> – Enzyme discovery, characterisation & engineering for enzymatic synthesis. Merging chemo- and biocatalysis for telescoping more sustainable routes to pharmaceuticals and other valuable products; 3) Nucleic acids chemistry and biology<\/a>, including developing new routes to nucleic acid therapeutics (NAT) and functional tools such as riboswitches and aptamers.<\/p>\n

To learn more about our research and lab culture watch this video produced by the RSC in recognition of our lab\u2019s recent RSC Horizon Prize – The Rita and John Cornforth Award (2023).<\/p>\n