{"id":533,"date":"2015-05-29T11:14:17","date_gmt":"2015-05-29T10:14:17","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=533"},"modified":"2015-07-22T12:20:50","modified_gmt":"2015-07-22T11:20:50","slug":"dr-david-t-hickman","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=533","title":{"rendered":"Dr. David T. Hickman"},"content":{"rendered":"

Publications:<\/span><\/p>\n

Superior nucleic acid binding properties of adeninyl pyrrolidine-amide oligonucleotide mimics (POM).<\/strong>\u00a0T.H.S. Tan, D.T. Hickman<\/strong>,\u00a0J. Morral, I.G. Beadham and J. Micklefield\u00a0Chem. Commun.<\/em>\u00a02004<\/strong>, 516-517. (http:\/\/dx.doi.org\/10.1039\/b315768g<\/a>)<\/p>\n

Design, synthesis, conformational analysis and nucleic acic hybridisation properties of thymidyl pyrrolidine-amid oligonuceotide mimics (POM).<\/strong>\u00a0D.T. Hickman<\/strong>, T.H.S. Tan,\u00a0J. Morral, P.M. King, M.A. Cooper and J. Micklefield\u00a0Org. Biomol. Chem.<\/em>\u00a02003<\/strong>, 1<\/em>, 3277-3292. (http:\/\/dx.doi.org\/10.1039\/b306156f<\/a>)<\/p>\n

Synthesis and nucleic-acid-binding properties of sulfamide and 3-N<\/em>-sulfamate modified DNA.<\/strong> K.J. Fettes, N. Howard,\u00a0D.T. Hickman<\/strong>, S.A. Adah, M.R. Player, P.F. Torrence and J. Micklefield\u00a0J. Chem. Soc., Perkin Trans.<\/em> 1\u00a02002<\/strong>, 485-495. (http:\/\/dx.doi.org\/10.1039\/b110603c<\/a>)<\/p>\n

Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM).<\/strong>\u00a0D.T. Hickman, P.M. King, J.M. Slater, M.A.Cooper and J. Micklefield\u00a0Nucleosides, Nucleotides & Nucleic Acids<\/em>\u00a02001<\/strong>, 20<\/em>, 1169-1172. (http:\/\/dx.doi.org\/10.1081\/NCN-100002512<\/a>)<\/p>\n

Unusual RNA & DNA binding properties of a novel pyrrolidine-amide oligonucleotide mimics (POM). D.T. Hickman<\/strong>, P.M. King, M.A. cooper, J.M. Slater and J. Micklefield\u00a0Chem.Commun.<\/em>\u00a02000<\/strong>, 2251-2252. (http:\/\/dx.doi.org\/10.1039\/b006903p<\/a>)<\/p>\n

Replacement of the phosphodiester linkage in DNA with sulfamide and 3′-N<\/em>-sulfamate groups.<\/strong> K. J. Fettes, N. Howard,\u00a0D.T. Hickman<\/strong>, S.A. Adadh, M.R. Player, P.F. Torrence and J. Micklefield\u00a0Chem. Commun.,<\/em> 2000<\/strong>, 765-766. (http:\/\/dx.doi.org\/10.1039\/b001586p<\/a>)<\/p>\n

Conference contributions, other (presenting author is underlined):<\/span><\/p>\n

A.I. Khan,<\/strong><\/span>\u00a0D.T. Hickman<\/strong>, T.H.S. Tan and J. Micklefield. “Synthesis and DNA\/RNA Binding properties of Second-generation Pyrrolidine amide Oligonucleotide Mimic (POM).”\u00a0RSC Postgraduate Symposium on Organic and Medicinal Chemistry<\/em>, Cambridge University, 9 Dec\u00a02002<\/strong>. (poster)<\/p>\n

T.H.S. Tan<\/span>,\u00a0J. Morral-Cardoner, D.T. Hickman<\/strong> and J. Micklefield. “Solid phase synthesis and biophysical studies of pyrrolidine-amide oligonucleotide mimics (POM).”\u00a0IUPAC 6th International Symposium of Bio-organic Chemistry<\/em>, Toronto, Canada, Aug 11-14,\u00a02002<\/strong>, pp. 75.<\/p>\n

T.H.S. Tan<\/span>, J. Micklefield and\u00a0D.T. Hickman<\/strong>. “Pyrrolidine-Amide Oligonucleotide Mimics (POM).”\u00a0RSC Bio-organic Group Postgraduate Symposium<\/em>, John Innes Centre, Norwich, 17 Dec\u00a02001.<\/strong> Samuel Tan won the Prize for best poster.<\/p>\n

T.H.S. Tan<\/span>, J. Micklefield and\u00a0D.T. Hickman<\/strong>. “Pyrrolidine-amide oligonucleotide mimics (POM): Synthesis and biophysical studies.”\u00a0NACON-V International Conference on Nucleic Acid Recognition<\/em>, University of Sheffield, 8-12 Apr\u00a02001<\/strong>. (poster).<\/p>\n

D.T. Hickman<\/strong>, P.M. King, J.M. slater, M.A. Cooper and\u00a0J. Micklefield<\/span>. “Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM).”\u00a0XIV International Roundtable: Nucleosides, Nucleotides and Their Biological Applications, San Francisco, USA, Sept\u00a02000<\/strong>. (poster).<\/p>\n

D.T. Hickman<\/strong><\/span>, J. Micklefield and J.M. Slater. “Postively charged pyrrolidine polyamide nucleic acid analogues.”\u00a0Royal Society of Chemistry 1999 Annual Conference<\/em>, Heriot-Watt Univ.,\u00a01999.<\/strong> (poster).<\/p>\n","protected":false},"excerpt":{"rendered":"

Publications: Superior nucleic acid binding properties of adeninyl pyrrolidine-amide oligonucleotide mimics (POM).\u00a0T.H.S. Tan, D.T. Hickman,\u00a0J. Morral, I.G. Beadham and J. Micklefield\u00a0Chem. Commun.\u00a02004, 516-517. (http:\/\/dx.doi.org\/10.1039\/b315768g) Design, synthesis, conformational analysis and nucleic acic hybridisation properties of thymidyl pyrrolidine-amid oligonuceotide mimics (POM).\u00a0D.T. Hickman, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-533","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=533"}],"version-history":[{"count":4,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/533\/revisions"}],"predecessor-version":[{"id":613,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/533\/revisions\/613"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}