{"id":521,"date":"2015-06-01T16:09:52","date_gmt":"2015-06-01T15:09:52","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=521"},"modified":"2015-06-29T13:08:38","modified_gmt":"2015-06-29T12:08:38","slug":"dr-t-h-samuel-tan","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=521","title":{"rendered":"Dr. T.H. Samuel Tan"},"content":{"rendered":"

Publications:<\/span><\/p>\n

Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA\/RNA binding properties.\u00a0<\/strong>R. Worthington, A. O’Rourke,\u00a0J. Morral, T.H.S. Tan<\/strong> and J. Micklefield Org. Biomol. Chem.,\u00a02007<\/strong>, 5<\/em>, 249-259. (http:\/\/dx.doi.org\/10.1039\/b613386j<\/a>)<\/p>\n

Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA\/RNA binding properties.\u00a0T.H.S. Tan<\/strong>,\u00a0R. Worthington, A. O’Rourke,\u00a0J. Morral, R.G. Pritchard and J. Micklefield\u00a0Org. Biomol.<\/em>\u00a0Chem.,\u00a02007<\/strong>, 5<\/em>, 239-248. (http:\/\/dx.doi.org\/10.1039\/b613384n<\/a>)<\/p>\n

These two\u00a0OBC<\/em>\u00a0papers were\u00a0highlighted on the front cover:\u00a0“Pyrrolidine amide oligonucleotide mimics (POM): Chemical biology solutions from zebrafish developmental biology through to high throughput DNA sequencing.”<\/p>\n

Effects of stereospecific backbone methylation on the DNA\/RNA binding properties of pyrrolidine-amide oligonucleotide mimics (cPOM). <\/strong>A. Khan, T.H.S. Tan<\/strong> and J. Micklefield\u00a0Chem.<\/em>\u00a0Commun.\u00a02006<\/strong>, 1436-1438. (http:\/\/dx.doi.org\/10.1039\/b518171b<\/a>)<\/p>\n

Superior nucleic acid binding properties of adeninyl pyrrolidine-amide oligonucleotide mimics (POM).<\/strong>\u00a0T.H.S. Tan<\/strong>, D.T. Hickman,\u00a0J. Morral, I.G. Beadham and J. Micklefield\u00a0Chem. Commun.<\/em>\u00a02004<\/strong>, 516-517. (http:\/\/dx.doi.org\/10.1039\/b315768g<\/a>)<\/p>\n

Design, synthesis, conformational analysis and nucleic acic hybridisation properties of thymidyl pyrrolidine-amid oligonuceotide mimics (POM).<\/strong>\u00a0D.T. Hickman, T.H.S. Tan<\/strong>,\u00a0J. Morral, P.M. King, M.A. Cooper and J. Micklefield\u00a0Org. Biomol. Chem.<\/em>\u00a02003<\/strong>, 1<\/em>, 3277-3292. (http:\/\/dx.doi.org\/10.1039\/b306156f<\/a>)<\/p>\n

Conference contributions, refereed:<\/span><\/p>\n

A.I. Khan, T.H.S. Tan<\/strong>,\u00a0J. Morral-Cardoner\u00a0and J. Micklefield “Synthesis and DNA\/RNA binding properties of conformationally restricted pyrrolidine-amide oligonucleotide mimics (POM).”\u00a0Abstr. Pap. Am. Chem. Soc.<\/em>\u00a02003<\/strong>, 226<\/em>, ORGN-510.<\/p>\n

Conference contributions, other (presenting author is underlined):<\/span><\/p>\n

A.I. Khan,<\/strong><\/span>\u00a0D.T. Hickman, T.H.S. Tan<\/strong> and J. Micklefield. “Synthesis and DNA\/RNA Binding properties of Second-generation Pyrrolidine amide Oligonucleotide Mimic (POM).”\u00a0RSC Postgraduate Symposium on Organic and Medicinal Chemistry<\/em>, Cambridge University, 9 Dec\u00a02002<\/strong>. (poster)<\/p>\n

T.H.S. Tan<\/strong><\/span>,\u00a0J. Morral-Cardoner, D.T. Hickman and J. Micklefield. “Solid phase synthesis and biophysical studies of pyrrolidine-amide oligonucleotide mimics (POM).”\u00a0IUPAC 6th International Symposium of Bio-organic Chemistry<\/em>, Toronto, Canada, Aug 11-14,\u00a02002<\/strong>, pp. 75.<\/p>\n

T.H.S. Tan<\/strong><\/span>, J. Micklefield and\u00a0D.T. Hickman. “Pyrrolidine-Amide Oligonucleotide Mimics (POM).”\u00a0RSC Bio-organic Group Postgraduate Symposium<\/em>, John Innes Centre, Norwich, 17 Dec\u00a02001.<\/strong>\u00a0Samuel Tan won the Prize for best poster.<\/p>\n

T.H.S. Tan<\/strong><\/span>, J. Micklefield and\u00a0D.T. Hickman. “Pyrrolidine-amide oligonucleotide mimics (POM): Synthesis and biophysical studies.”\u00a0NACON-V International Conference on Nucleic Acid Recognition<\/em>, University of Sheffield, 8-12 Apr\u00a02001<\/strong>. (poster).<\/p>\n","protected":false},"excerpt":{"rendered":"

Publications: Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA\/RNA binding properties.\u00a0R. Worthington, A. O’Rourke,\u00a0J. Morral, T.H.S. Tan and J. Micklefield Org. Biomol. Chem.,\u00a02007, 5, 249-259. (http:\/\/dx.doi.org\/10.1039\/b613386j) Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA\/RNA binding properties.\u00a0T.H.S. Tan,\u00a0R. Worthington, A. O’Rourke,\u00a0J. Morral, … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-521","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/521","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=521"}],"version-history":[{"count":2,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/521\/revisions"}],"predecessor-version":[{"id":598,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/521\/revisions\/598"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=521"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}