{"id":488,"date":"2015-05-26T15:02:10","date_gmt":"2015-05-26T14:02:10","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=488"},"modified":"2015-06-29T13:01:56","modified_gmt":"2015-06-29T12:01:56","slug":"dr-matthew-borg","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=488","title":{"rendered":"Dr. Matthew Borg"},"content":{"rendered":"<p><span style=\"text-decoration: underline;\">Publications:<\/span><\/p>\n<p><strong>Engineered biosynthesis of nonribosomal lipopeptide antibiotics with modified fatty acid side chains<\/strong>.\u00a0A. Powell, <strong>M. Borg<\/strong>, B. Amir-Heidari, J.M. Neary,\u00a0J. Thirlway, B. Wilkinson, C.P. Smith and J. Micklefield\u00a0<em>J. Am. Chem. Soc.<\/em>\u00a0<strong>2007<\/strong><em>, 129<\/em>, 15182-15191. Articles based on this paper were published in the\u00a0Daily Express, Chemistry &amp; Industry, Manchester Evening News\u00a0see below. (<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja074331o\">http:\/\/dx.doi.org\/10.1021\/ja074331o<\/a>)<\/p>\n<p><strong>Active-site modifications of adenylation domains leads to hydrolysis of upstream nonribosomal peptidyl thioester intermediates.\u00a0<\/strong>G.C. Uguru, C. Milne,\u00a0<strong>M. Borg<\/strong>, F. Flett, C.P. Smith and J. Micklefield\u00a0<em>J. Am. chem.<\/em> Soc.<strong> 2004<\/strong><em>, 126<\/em>, 5032-5033. (<a href=\"http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja048778y\">http:\/\/dx.doi.org\/10.1021\/ja048778y<\/a>)<\/p>\n<p><strong>Structure, biosynthetic origin, and engineered biosynthesis of calcium-dependent antibiotics from\u00a0<em>Streptomyces coelicolor<\/em><\/strong>. Z. Hojati, C. Milne, L. Gordon,\u00a0<strong>M. Borg<\/strong>, F. Flett, B. Wilkinson, P. J. Sidebottom, B.A.M. Rudd, M.A. Hayes, C.P. Smith and J. Micklefield\u00a0<em>Chemistry &amp; Biology<\/em>\u00a0<strong>2002<\/strong><em>, 9<\/em>, 1175-1187. (<a href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1074552102002521\">http:\/\/dx.doi.org\/10.1016\/s1074-5521(02)00252-1<\/a>). Featured as the lead article and was illustrated on the fron cover &#8220;<em>Chemobiosynthesis leads to new lipopeptide antibiotics&#8221;.<\/em> This paper was also reviewed &#8220;<em>New compounds by combining modern genomics and old-fashioned mutasynthesis&#8221;<\/em> by Wohlleben, W.; Pelzer, S. Chemistry &amp; Biology\u00a0<strong>2002<\/strong>,<em> 9<\/em>, 1163<\/p>\n<p><span style=\"text-decoration: underline;\">Conference contributions, other (presenting author is underlined):<\/span><\/p>\n<p><span style=\"text-decoration: underline;\"><strong>M. Borg<\/strong><\/span>, J. Micklefield, C.P. Smith. &#8220;The fatty acid biosynthesis Operon in the CDA cluster&#8221;\u00a0<em>Abstracts of the 9th International Symposium on the genetics of industrial microorganisms<\/em> (GIM), Gyongju, Korea, 1-5 July,\u00a0<strong>2002<\/strong>, pp. 88.<\/p>\n<p><span style=\"text-decoration: underline;\">J. Micklefield<\/span>, A.E. Hayes, Z. H. Najafabadi, G.C. Uguru,\u00a0J.M. Neary, C. Milne, L. Gordon, J. Jim, <strong>M. Borg<\/strong>, F. Flett and C.P. Smith. &#8220;CDA biosynthesis: towards the engineered biosynthesis of novel lipopeptide antibiotics.&#8221;\u00a0<em>BBSRC Workshop on Natural Products Biology<\/em>, University of Warwick, 21-22 May\u00a0<strong>2001<\/strong> (poster)<\/p>\n<p>J. Micklefield, A.E. Hayes, Z. H. ajafabadi, G.C. Uguru, J.M. Neary, C. Milne, L. Gordon, J. Jim,\u00a0<strong>M. Borg<\/strong>, F. Flett and\u00a0<span style=\"text-decoration: underline;\">C.P. Smith<\/span>. &#8220;Characterisation of the nonribosomal peptide synthetases and other key enzymes involved in CDA biosynthesis: Towards the engineered biosynthesis of novel lipopeptide antibiotics.&#8221;\u00a0<em>Conference on Streptomyces<\/em>, University of Warwick, Feb\u00a0<strong>2001<\/strong>. (Poster).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications: Engineered biosynthesis of nonribosomal lipopeptide antibiotics with modified fatty acid side chains.\u00a0A. Powell, M. Borg, B. Amir-Heidari, J.M. Neary,\u00a0J. Thirlway, B. Wilkinson, C.P. Smith and J. Micklefield\u00a0J. Am. Chem. Soc.\u00a02007, 129, 15182-15191. Articles based on this paper were published &hellip; <a href=\"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=488\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-488","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=488"}],"version-history":[{"count":4,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/488\/revisions"}],"predecessor-version":[{"id":494,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/488\/revisions\/494"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}