{"id":462,"date":"2015-05-26T12:22:10","date_gmt":"2015-05-26T11:22:10","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=462"},"modified":"2015-06-29T14:07:40","modified_gmt":"2015-06-29T13:07:40","slug":"professor-roberta-worthington","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=462","title":{"rendered":"Professor Roberta Worthington"},"content":{"rendered":"

Publications:<\/span><\/p>\n

Biophysical and Cellular Uptake Properties of Mixed Sequence Pyrrolidine-amide Oligonucleotide Mimics. R. Worthington<\/strong> and J. Micklefield\u00a0Chem. Eur.<\/em> J., 2011<\/strong>, 17<\/em>, 14429-14441 (http:\/\/dx.doi.org\/10.1002\/chem.201101950<\/a>)<\/p>\n

RNA selective cross-pairing of backbone extended pyrrolidine-amide oligonucleotide mimics (bePOMs). R. Worthington<\/strong>, N. Bell and J. Micklefield\u00a0Org. Biomol.<\/em> Chem. 2008<\/strong>, 6,<\/em> 92-103. (http:\/\/dx.doi.org\/10.1039\/b714580m<\/a>)<\/p>\n

Mixed-sequence pyrrolidine-amide oligonucleotide mimics: Boc(Z) synthesis and DNA\/RNA binding properties. R. Worthington<\/strong>, A. O’Rourke, J. Morral, T.H.S. Tan and J. Micklefield Org. Biomol. Chem., 2007<\/strong>, 5<\/em>, 249-259. (http:\/\/dx.doi.org\/10.1039\/b613386j<\/a>)<\/p>\n

Homopolymeric pyrrolidine-amide oligonucleotide mimics: Fmoc-synthesis and DNA\/RNA binding properties.\u00a0<\/strong>T.H.S. Tan,\u00a0R. Worthington<\/strong>, A. O’Rourke, J. Morral, R.G. Pritchard and J. Micklefield\u00a0Org. Biomol.<\/em> Chem., 2007<\/strong>, 5<\/em>, 239-248. (http:\/\/dx.doi.org\/10.1039\/b613384n<\/a>)<\/p>\n

These two\u00a0OBC<\/em> papers were\u00a0highlighted on the front cover:<\/span> “Pyrrolidine amide oligonucleotide mimics (POM): Chemical biology solutions from zebrafish developmental biology through to high throughput DNA sequencing.”<\/p>\n

Conference contributions, refereed:<\/span><\/p>\n

Bell, Neil M.;\u00a0Worthington, Roberta J.;<\/strong> Micklefield, Jason. Nucleic acid redesign, recognition and transcription: The pyrrolidine-amide oligonucleotide mimics. Abstracts of Papers, 236th ACS National Meeting, Philadelphia, PA, United States, August 17-21, 2008 (2008), BIOL-171<\/p>\n

Bell, Neil M.;\u00a0Worthington, Roberta J.;<\/strong> Micklefield, Jason. Nucleic acid redesign and recognition:\u00a0The pyrrolidine-amide oligonucleotide mimics (POMs). Collection Symposium Series (2008), 10 (Chemistry of Nucleic Acid Components), 206-209.<\/p>\n

A.P. O’Rourke,\u00a0R.J. Worthington<\/strong>, J. Morral and J. Micklefield “Synthesis and UV hybridization studies of mixed-sequence pyrrolidine-amide oligonucleotide mimics (POM).”\u00a0Abstr. Pap. Am. Chem.<\/em> Soc. 2005<\/strong>, 230<\/em>, ORGN-605.<\/p>\n

Conference contributions, other (presenting author is underlined)<\/span><\/p>\n

R. Wong<\/span>,\u00a0R. Worthington<\/strong>, J. Micklefield “Synthesis and biophysical studies of pyrrolidine-amide oligonucleotide mimic (POM) and non-enzymatic transcription of nucleic acids.”\u00a0EPSRC Synthetic Studentship Review<\/em>, Jury’s Inn Birmingham, 27 June\u00a02007<\/strong>. (Poster)<\/p>\n

R. Worthington<\/strong><\/span>, N. Bell, A. O’Rourke, J. Micklefield “Redesigning nature’s genetic material: pyrrolidine amide oligonucleotide mimics”\u00a0RSC Bio-organic Chemistry Annual Meeting.\u00a0<\/em>MIB Manchester, 18 Dec\u00a02006.<\/strong> (Poster)<\/p>\n

R. Worthington<\/strong><\/span>, A. O’Rourke, J. Micklefield “Synthesis and DNA\/RNA binding properties of mixed sequence pyrrolidine amide oligonucleotide mimics”\u00a0RSC Nucleic Acids Forum<\/em>, MIB Manchester 7 July\u00a02006.<\/strong> (Poster).<\/p>\n","protected":false},"excerpt":{"rendered":"

Publications: Biophysical and Cellular Uptake Properties of Mixed Sequence Pyrrolidine-amide Oligonucleotide Mimics. R. Worthington and J. Micklefield\u00a0Chem. Eur. J., 2011, 17, 14429-14441 (http:\/\/dx.doi.org\/10.1002\/chem.201101950) RNA selective cross-pairing of backbone extended pyrrolidine-amide oligonucleotide mimics (bePOMs). R. Worthington, N. Bell and J. Micklefield\u00a0Org. … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-462","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/462","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=462"}],"version-history":[{"count":5,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/462\/revisions"}],"predecessor-version":[{"id":466,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/462\/revisions\/466"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=462"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}