Jenny gained her PhD at the University of Nottingham. Following on from her time with the Micklefield lab, she moved onto\u00a0Eden Biodesign Ltd, National Biomanufacturing Centre, Estuary Banks, Liverpool.<\/p>\n
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Publications:<\/span><\/p>\n Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity.\u00a0J. Thirlway<\/strong>, R. Lewis, L. Nunns, M. Al Nakeeb,\u00a0M. Styles,\u00a0A.-W. Struck, C.P. Smith and J. Micklefield\u00a0Angew. Chem. Int. Ed<\/em>\u00a02012<\/strong>, 51,<\/em>\u00a07181-7184 (http:\/\/dx.doi.org\/10.1002\/anie.201202043<\/a>)<\/p>\n Active site modification of the<\/strong>\u00a0\u1e9e-ketoacyl-ACP synthase FabF3 of\u00a0Streptomyces coelicolor<\/span><\/strong>\u00a0affects the fatty acid chain length of CDA lipopeptides.\u00a0<\/strong>R. A. Lewis, L. Nunns, J. Thirlway<\/strong>, K. Carroll, C.P. Smith and J Micklefield\u00a0Chem. Commun.<\/em>\u00a02011<\/strong>, 47<\/em>, 1860-1862. (http:\/\/dx.doi.org\/10.1039\/c0cc03444d<\/a>)<\/p>\n Direct site-selective covalent protein immobilization catalyzed by a phosphopantetheinyl transferase.\u00a0<\/strong>L.S. Wong,\u00a0J. Thirlway<\/strong>, and J. Micklefield\u00a0J. Am. Chem. Soc.<\/em>\u00a02008<\/strong>, 1430,\u00a0<\/em>12456-12464. (http:\/\/dx.doi.org\/10.1021\/ja8030278<\/a>)<\/p>\n Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues.\u00a0<\/strong>B. Amir-Heidari,\u00a0J. Thirlway<\/strong>, and J. Micklefield\u00a0Org. Biomol. Chem.<\/em>\u00a02008,<\/strong> 6,<\/em> 975-978. Highlighted on the front cover. (http:\/\/dx.doi.org\/10.1039\/b718766c<\/a>)<\/p>\n Engineered biosynthesis of nonribosomal lipopeptide antibiotics with modified fatty acid side chains<\/strong>.\u00a0A. Powell, M. Borg, B. Amir-Heidari, J.M. Neary,\u00a0J. Thirlway<\/strong>, B. Wilkinson, C.P. Smith and J. Micklefield\u00a0J. Am. Chem. Soc.<\/em>\u00a02007<\/strong>, 129<\/em>, 15182-15191. Articles based on this paper were published in the\u00a0Daily Express, Chemistry & Industry, Manchester Evening News<\/span> see below. (http:\/\/dx.doi.org\/10.1021\/ja074331o<\/a>)<\/p>\n Stereospecific enzymatic transformation of a-ketoglutarate to (2S,<\/em>3R<\/em>)-3-methyl glutamate during acidic lipopeptide biosynthesis.<\/strong> C. Mahlert, F. Kopp,\u00a0J. Thirlway<\/strong>, J. Micklefield and M.A. Marahiel\u00a0J. Am. Chem. Soc<\/em>\u00a02007<\/strong>, 129<\/em>, 12011-12018. (http:\/\/dx.doi.org\/10.1021\/ja074427i<\/a>)<\/p>\n Stereochemical course of tryptophan dehydrogenation during calcium-dependent lipopeptide antibiotic biosynthesis.\u00a0<\/strong>B.A. Heidari,\u00a0J. Thirlway<\/strong> and J. Micklefield\u00a0Org. Lett.<\/em>\u00a02007<\/strong>, 9<\/em>, 1513-1516. (http:\/\/dx.doi.org\/10.1021\/ol0701619<\/a>)<\/p>\n Patents<\/span><\/p>\n R. Lewis, C. Smith, J. Thirlway<\/strong>, J. Micklefield,\u00a0L. Nunns, “Novel calcium dependent antibiotic variants with modified fatty acid side-chains produced by\u00a0streptomyces<\/em>\u00a0strains expressing a mutant\u00a0\u1e9e-ketoacyl-ACP synthase II gene” Brit. UK Pat Appl. (2012), GB 2483075 A 20120229<\/p>\n Conference contributions, other (presenting author is underlined)<\/span><\/p>\n J. Thirlway<\/strong>, J. Micklefield “Biosynthetic engineering of nonribosomal peptide antibiotics.”\u00a0The Chemistry and Biology of Natural Product Biosynthesis III.<\/em> School of Chemistry, University of Bristol, June 20\u00a02007<\/strong>. (oral\/abstract)<\/p>\n L.S. Wong<\/span>,\u00a0J. Thirlway<\/strong>, J. Micklefield “Site-selective covalent protein immobilization catalysed by a promiscuous phosphopantetheinyl transferase.”\u00a0Surface Science for Biologically Important Interfaces (SSBII) 9th Annual Meeting<\/em>, Manchester, 13-14 Sept\u00a02007<\/strong>. (oral\/abstract)<\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" Jenny gained her PhD at the University of Nottingham. Following on from her time with the Micklefield lab, she moved onto\u00a0Eden Biodesign Ltd, National Biomanufacturing Centre, Estuary Banks, Liverpool. Publications: Introduction of a Non-Natural Amino Acid into a Nonribosomal … Continue reading