{"id":427,"date":"2015-05-19T13:28:02","date_gmt":"2015-05-19T12:28:02","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=427"},"modified":"2015-09-16T12:46:48","modified_gmt":"2015-09-16T11:46:48","slug":"dr-laura-nunns","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=427","title":{"rendered":"Dr. Laura Nunns"},"content":{"rendered":"<p><span style=\"text-decoration: underline;\">Publications<\/span>:<\/p>\n<p><strong>Engineered Biosynthesis of Enduracidin Lipoglycopeptide Antibiotics using the Ramoplanin Mannosyltransferase Ram29.\u00a0<\/strong>M.-C. Wu<strong>,\u00a0<\/strong>M.Q. Styles, <strong>L. Nunns<\/strong>, B.J.C. Law, J. Micklefield\u00a0<strong>2015<\/strong> <em>161: 1338-1347<\/em><em>\u00a0<\/em>DOI:<a href=\"http:\/\/dx.doi.org\/10.1099\/mic.0.000095\">10.1099\/mic.0.000095<\/a><\/p>\n<p><strong>Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity.\u00a0<\/strong>J. Thirlway, R. Lewis, <strong>L. Nunns<\/strong>, M. Al Nakeeb,\u00a0M. Styles,\u00a0A.-W. Struck, C.P. Smith and J. Micklefield\u00a0<em>Angew. Chem. Int. Ed<\/em>\u00a0<strong>2012<\/strong><em>, 51,<\/em>\u00a07181-7184 (<a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201202043\/abstract\">http:\/\/dx.doi.org\/10.1002\/anie.201202043<\/a>)<\/p>\n<p><strong>Active site modification of the<\/strong>\u00a0<strong>\u1e9e-ketoacyl-ACP synthase FabF3 of\u00a0Streptomyces coelicolor<\/strong><strong>\u00a0affects the fatty acid chain length of CDA lipopeptides.\u00a0<\/strong>R. A. Lewis, <strong>L. Nunns<\/strong>, J. Thirlway, K. Carroll, C.P. Smith and J Micklefield\u00a0<em>Chem. Commun.<\/em>\u00a0<strong>2011<\/strong><em>, 47<\/em>, 1860-1862. (<a href=\"http:\/\/pubs.rsc.org\/en\/Content\/ArticleLanding\/2011\/CC\/C0CC03444D#!divAbstract\">http:\/\/dx.doi.org\/10.1039\/c0cc03444d<\/a>)<\/p>\n<p><span style=\"text-decoration: underline;\">Patents<\/span><\/p>\n<p>R. Lewis, C. Smith, J. Thirlway, J. Micklefield,\u00a0<strong>L. Nunns<\/strong>, &#8220;Novel calcium dependent antibiotic variants with modified fatty acid side-chains produced by\u00a0<em>streptomyces<\/em> strains expressing a mutant\u00a0\u1e9e-ketoacyl-ACP synthase II gene&#8221; Brit. UK Pat Appl. (2012), GB 2483075 A 20120229<\/p>\n<p><span style=\"text-decoration: underline;\">Conference contributions, other (presenting author is underlined)<\/span><\/p>\n<p><span style=\"text-decoration: underline;\">M. Styles<\/span>,\u00a0M.-C. Wu, <strong>L. Nunns<\/strong>, B. Law, J. Micklefield, &#8220;Combinatorial Biosynthesis of Non-Ribosomal Peptide Antibiotics&#8221; 2nd RSC Symposium on Chemical Biology for Drug Discovery, 2012 March 20-21, Alderley Park Conference Centre, Cheshire, UK<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Publications: Engineered Biosynthesis of Enduracidin Lipoglycopeptide Antibiotics using the Ramoplanin Mannosyltransferase Ram29.\u00a0M.-C. Wu,\u00a0M.Q. Styles, L. Nunns, B.J.C. Law, J. Micklefield\u00a02015 161: 1338-1347\u00a0DOI:10.1099\/mic.0.000095 Introduction of a Non-Natural Amino Acid into a Nonribosomal Peptide Antibiotic by Modification of Adenylation Domain Specificity.\u00a0J. Thirlway, &hellip; <a href=\"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=427\">Continue reading <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-427","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/427","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=427"}],"version-history":[{"count":6,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/427\/revisions"}],"predecessor-version":[{"id":632,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/427\/revisions\/632"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=427"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}