{"id":314,"date":"2014-04-02T18:03:21","date_gmt":"2014-04-02T17:03:21","guid":{"rendered":"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=314"},"modified":"2016-04-13T14:53:00","modified_gmt":"2016-04-13T13:53:00","slug":"dr-ying-zhuo","status":"publish","type":"page","link":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/?page_id=314","title":{"rendered":"Dr. Ying Zhuo"},"content":{"rendered":"

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Dr. Ying Zhuo<\/strong> received her MS degree in microbiology from Nanjing Agriculture University (2005). Following her PhD studies with Professor Lixin Zhang in Institute of Microbiology, Chinese Academy of Sciences (2007-2010), she began her academic career as an Assistant Professor of biochemistry and molecular biology in IMCAS. She joined the Micklefield group in 2014 and her work is involved in the engineering of biosynthesis genes for improved production and structure diversification of natural products. Her research interests include synthetic biology, understanding biosynthetic and regulatory mechanisms of microbial secondary metabolism, pathway engineering and functional genomics of antibiotic producers.<\/p>\n

Selected publications:<\/strong><\/p>\n

An Enzyme Cascade for Selective Modification of Tyrosine Residues in Structurally Diverse Peptides and Proteins.\u00a0<\/strong>A.-W. Struck, M. R. Bennett, S. A. Shepherd, B. J. C. Law, Y. Zhou<\/strong>, L. S. Wong, J. Micklefield\u00a0<\/strong> J. Am. Chem. Soc.<\/em>\u00a0 2016 <\/em><\/strong>138,\u00a0<\/em>3038-3045.\u00a0 (http:\/\/dx.doi.org\/10.1021\/jacs.<\/a><\/p>\n

Recent Advances in Engineering Non-Ribosomal Peptide Assembly Lines.\u00a0<\/strong>\u00a0M. Winn, J. Fyans, Y. Zhou<\/strong>, J. Micklefield\u00a0Nat. Prod. Rep<\/em>.2016<\/strong>, 33,\u00a0<\/em>317-347\u00a0<\/em>(http:\/\/dx.doi.org\/10.1039\/C5NP00099H<\/a>)<\/p>\n

Reverse biological engineering of hrdB to enhance the production of avermectins in an industrial strain of Streptomyces avermitilis<\/em>.\u00a0Zhuo Y, <\/strong>Zhang W, Chen D, Gao H, Tao J, Liu M, Gou Z, Zhou X, Ye BC, Zhang Q, Zhang S, Zhang LX. (2010<\/strong>) \u00a0Proc Natl Acad Sci U S A<\/em> 107 (25):11250-11254.<\/p>\n

Resequencing of Burkholderia thailandensis<\/em> MSMB43 with Improved Annotation and Revised Genome Sequence<\/strong>.\u00a0Zhuo Y<\/strong>, Liu L, Wang Q, Liu X, Ren B, Liu M, Ni P,Cheng Yi-Qiang, Zhang L. (2012<\/strong>) \u00a0J Bacteriol<\/em>. 194 (17): 4749-4750.<\/p>\n

Cloning and characterization of the gene cluster required for beauvericin biosynthesis in Fusarium proliferatum<\/em><\/strong>.\u00a0Zhang T#<\/sup>, Zhuo Y<\/strong>#<\/sup><\/strong>, Jia X, Liu J, Gao H, Song F, Liu M, Zhang L. (2013<\/strong>) \u00a0Science China Life Sciences <\/em>56(7):628-637.<\/p>\n

Overexpression of the ABC transporter AvtAB increases avermectin production in Streptomyces avermitilis<\/em><\/strong>.\u00a0Qiu J#<\/sup>, Zhuo Y<\/strong>#<\/sup>, Zhu D, Zhou X, Zhang L, Bai L, Deng Z. (2011<\/strong>) Appl Microbiol Biotechnol <\/em>92(2):337-345.<\/p>\n

Assessing the potential of an induced-mutation strategy for avermectin overproducers.\u00a0<\/strong>Gao H#<\/sup>, Liu M#<\/sup>, Zhuo Y<\/strong>#<\/sup>, Zhou X, Liu J, Chen D, Zhang W, Gou Z, Shang P, Zhang L (2010<\/strong>) \u00a0Appl Environ Microbiol <\/em>76 (13):4583-4586.<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Dr. Ying Zhuo received her MS degree in microbiology from Nanjing Agriculture University (2005). Following her PhD studies with Professor Lixin Zhang in Institute of Microbiology, Chinese Academy of Sciences (2007-2010), she began her academic career as an Assistant Professor … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-314","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=314"}],"version-history":[{"count":11,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/314\/revisions"}],"predecessor-version":[{"id":755,"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=\/wp\/v2\/pages\/314\/revisions\/755"}],"wp:attachment":[{"href":"https:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}