![\"\"](\"http:\/\/www.micklefieldlab.chemistry.manchester.ac.uk\/wp-content\/uploads\/2014\/04\/Phill2.jpg\" "\\"Phill2\\"")
<\/a>Phillip Lowe<\/strong>\u00a0studied for a MChem degree at the University of Manchester from 2006-2010. During his fourth year MChem project, his research involved the reengineering of the adenine-responsive add A<\/em>-riboswitch, specifically the design and synthesis of pyrimidine based ligands used to regulate gene expression with the mutant add A<\/em>-riboswitches.<\/p>\nIn 2010 Phillip continued his work with the Micklefield group by studying for a PhD in the area of Biological Chemistry. He is currently researching the reengineering of a PreQ1<\/sub> binding riboswitch. His work focuses on generating an orthogonal \u2018transcriptionally OFF\u2019 riboswitch for dynamic control of gene expression with synthetic PreQ1<\/sub> analogues in vivo<\/em>, as well as the in vitro<\/em> characterisation of riboswitch RNA-Ligand binding events.<\/p>\n Phillip has experience in organic synthesis, biological chemistry and RNA; synthesis, purification and in vitro analysis. Along with analytical and characterisation techniques including; FPLC, HPLC, mass spectrometry, ITC, DSC and NMR.<\/p>\n Outside of the lab Phillip trains and teaches martial arts, and has a keen interest in football. He also enjoys socialising at the pub, providing a decent range of craft ale is available.<\/p>\n Publications:<\/span><\/p>\n Rational Re-engineering of the Transcriptional Silencing PreQ1 Riboswitch.\u00a0<\/strong>M.-C. Wu, P.T. Lowe<\/strong>, C.J. Robinson, H.A. Vincent, N. Dixon, J. Leigh, J. Micklefield\u00a0J. Am. Chem. Soc.<\/em> 2015<\/strong> 137,\u00a0<\/em>9015-9021\u00a0(http:\/\/dx.doi.org\/10.1021\/jacs.5b03405<\/a>)<\/p>\n Modular Riboswitch Toolsets for Synthetic Genetic Control in Diverse Bacterial Species.\u00a0<\/strong>C.J. Robinson, H.A. Vincent,\u00a0M.-C. Wu, P.T.Lowe<\/strong>, M.S. Duncan, D. Leys, and J. Micklefield\u00a0J. Am. Chem. Soc.\u00a0<\/em>2014<\/strong>, 136, 10615-10624. DOI:\u00a010.1021\/ja502873j\u00a0<\/a><\/p>\n Conference contributions, other (presenting author is underlined)<\/span><\/p>\n C.J. Robinson<\/span>, N. Dixon, J.N. Duncan, T. Geerlings, M.-C. Wu,\u00a0P. Lowe<\/strong>, J. Micklefields, “Orthogonal Riboswitches As Tools for Controlling Gene Expression in Bacteria,” RNA 2012: The 17th Annual Meeting of the RNA Society, The University of Michigan, Ann Arbor, Mi, USA. May 29-Jun 2, 2012<\/p>\n","protected":false},"excerpt":{"rendered":" Phillip Lowe\u00a0studied for a MChem degree at the University of Manchester from 2006-2010. During his fourth year MChem project, his research involved the reengineering of the adenine-responsive add A-riboswitch, specifically the design and synthesis of pyrimidine based ligands used … Continue reading