Members

Postdoctoral Research Associates                          

Sept 2017-          Dr Wei-Li Thong (BBSRC) “A Synthetic Biology Approach for the Total Biosynthesis of Semi-Synthetic Antibiotics”

Sept 2016-       Dr Duncan Smith (BBSRC) “A Synthetic Biology Approach for the Total Biosynthesis of Semi-Synthetic Antibiotics”

June 2016-      Dr Lujing Ren, Nanjing Tech University, China.         

Sept 2015-       Dr Matthew Bennett (BBSRC), “Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts”

Sept  2014–      Dr Brian Law (BBSRC), “Natural products biosynthesis & bioengineering,”

Mar 2014–       Dr  Sarah Shepherd (BBSRC) NPRONET project manager.

Mar 2014–       Dr Ying Zhuo  (BBSRC) “Bioengineering of next generation lipoglycopeptide antibiotics.”

Mar 2014–       Dr Joanna Fyans (BBSRC) “Bioengineering of next generation lipoglycopeptide antibiotics.”

Aug 2013–       Dr Michael Winn (BBSRC) “Natural products biosynthesis & bioengineering,”

June 2013–      Dr Binuraj Menon (BBSRC) “Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts.”

Feb 2012-15    Dr Helen A. Vincent (BBSRC) “Orthogonal riboswitches as tools for controlling gene expression in bacteria.”

Jan 2012-13    Dr Ming Cheng Wu (BBSRC)  “Orthogonal riboswitches as tools for controlling gene expression in bacteria.”

Oct 2011-15    Dr Anna-Winona Struck (BBSRC) “Bioorthogonal site-selective protein immobilisation and labelling.”

Nov 2011-15   Dr Mark Thompson (BBSRC) “Rapid Evolution of Enzymes and Synthetic Micro-organisms for the Development of Industrial Biocatalysts”

Nov 2009-15    Dr Christopher Robinson (BBSRC) “Riboswitches.”

May 2006-10  Dr Neil Dixon (BBSRC) “Riboswitches.”

June 2006-09  Dr Krzysztof Okrasa (BASF-CoEBio3) “New malonate decarboxylase enzymes”

May 2006-10  Dr Torsten Geerlings (BBSRC) “Riboswitches.”

Sept 2005-09   Dr Lu Shin Wong (EPSRC) “Nanoscale arrays for near single biomolecular detection.”

Mar 2005-08   Dr Jenny Thirlway (BBSRC) “Engineering the biosynthesis of nonribosomal peptide antibiotics.”

Dec 2006-07   Dr Raymond Wong (EPSRC) “DNA template directed synthesis”

April 2004-05  Dr Simon Saul (INEOS Fluor). “Biotransformations in HFC solvents II.”

Jan 2003-05     Dr Ian Beadham (EPSRC). “Synthesis and nucleic acid binding properties of de novo zwitterionic pyrrolidine-phosphonate oligonucleotide mimics.”

Jan 2002-05    Dr Jordi Morral Cardoner, (BBSRC).  “Solid phase synthesis and nucleic acid binding properties of mixed sequence pyrrolidine-amide oligonucleotide mimics.”

Sept 2000-03   Dr Gabriel Chukwu Uguru (BBSRC). “Combinatorial biosynthesis of lipopeptide antibiotics.”

 

PhD Postgraduate Students

2017-               Abigail Herbert  (MChem University of Leicester)

2017-               Catherine Lowe

2017-               Elliot Craven

2017-                Varvara Androulaki

2017-                Alberto Carella

2017-                Saadia Irfan

2016-               Helen Taylor (University of Liverpool)

2016-               Yingxin Zhang (China)

2015-2016     Martha Ferrer Rios (Mexico) completed MPhil

2014- 2018     Jean-Marc Henry (France)

2013-2017       Jonathan Latham (MChem Manchester) “Integrated Catalysis: Biohalogenation and transition metal-catalysed cross coupling cascade reactions in water”

2013-2017       Eileen Brandenburger (BSc and MSc Justus-Liebig-University, Giessen, Germany

2013-2017        Daniel Francis (MChem Univ of Leicester) “Natural products chemical biology”

2013-2017        Victoria Ann Cronin (BSc (Hons) Biochemistry, University of Bath with one year at the University of Colorado, USA) “Alkyltransferases as synthetic tools”

2013-               Humera Sharif (MChem Manchester)

2013-2017     Heidi Fisk (Mchem, University of Nottingham) “Biological and analytical chemistry for development of halogenase enzymes”

2012-               Daniel Medina Stacey (Bachelors Degree in Genetics, Universidad Complutense de Madrid & MSc Bioinformatics University of Manchester) “Riboswitch expression tools for plant chloroplasts”

2011-2015       Dr Angelica Jimenez (Masters in Chemistry & Bachelor’s Degree in Pharmaceutical Biochemistry from the University of the State of Mexico) “Biosynthesis of lipopeptide antibiotics”

2011-2015       Dr Mathew Bennett (MChem University of Bristol) “Alkyltransferases”

2011-2015       Dr James Leigh (MChem Manchester) “Orthogonally Selective Riboswitches for Controlling Gene Expression in Bacteria.”

2010-2014       Dr Ross Lewin (MChem Manchester) “Structure-Guided Directed Evolution of Malonate Decarboxylases and Related Enzymes”

2010-2014       Dr Philip Lowe (MChem Manchester) “Tuneable riboswitches for controlling gene expression with synthetic small molecules.”  PDRA with Prof David O’Hagan, Univ of St Andrews.

2010-2014       Dr Brian Law (BSc Cell Biology with Industrial Experience, FLS University of Manchester) A synthetic biology approach for engineering the biosynthesis for new friulimicin lipopeptide antibiotics.”

2010-2014       Dr Sarah Shepherd (MChem, University of Warwick). “Halogenase enzymes”

2009-2013       Dr Matthew Styles (MChem Durham)” A synthetic biology approach for engineering lipoglycopeptide antibiotics”

2009-2013       Dr Chinnan Karthikeyan (India) “Biosynthetic enginnering of antibiotics and biocatalysis”

2008-2012       Dr Laura Nunns (MChem, Univ of Manchester,  BBSRC EPS faculty quota (3 years)) “New methods for site specific protein immobilisation.”

2008-2012       Dr Mark Goodall (BSc Univ of Manchester)

2008-2011       Dr Ming Cheng Wu (Taiwan)

2008-2010       Tudor Grecu (MChem Sheffield)

2007-2011       Dr Mathew Wilding (MChem University of Manchester) “Redesign and directed evolution of new racemase enzymes.”

2007-2011       Dr Chris Chesters (MChem University of Manchester) “Redesign and directed evolution of aminomutase enzymes for preparation of homochiral b-aminoacids.”

2007-2011       Michael Power (MChem University of Manchester) “Nucleic acid recognition and DNA template directed synthesis.”

2006-2010       Dr John Duncan (Molecular Biology, University of Huddersfield) “Riboswitches & small molecule modulators of gene expression.” PDRA position, School of Life Science, University of Warwick.

2006-2010       Dr Mitchel Jacobs (MChem, University of Manchester) “Riboswitches and Nucleic acid recognition.” PDRA, Department of Chemistry, The Scripps Research, Institute, La Jolla, California, with Prof Ramanarayanan Krishnamurthy.

2005-2009       Dr Neil Bell (Chemistry, University of Leeds) “ Synthesis and biophysical evaluation of backbone extended pyrrolidine-amide oligonucleotide mimics.” PDRA University of Cambridge, now R&D Scientist at Cambridge Epigenetix.

2004-2008       Professor Roberta Worthington (MChem) “ Synthesis and biophysical evaluation of pyrrolidine-amide oligonucleotide mimics.” Roberta was a post-doctoral research associate working in the Medicinal Chemistry group at the Wolfson Institute for Biomedical Research, University College London. Currently Roberta is Assistant Professor at North Carolina State University.

2004-2008       Dr Majid Al Nakeeb (Iraq) “Synthetic studies related to the biosynthesis of acidic lipopeptide antibiotics.” JM lab technician, then PDRA in Chemistry at the University of Newcastle

2003-2007       Dr Amanda Jane Powell (Biochemistry, University of Wales, Aberystwyth) “Engineering the biosynthesis of lipopeptide antibiotics” Amanda is a Mass Spec Support Specialist, Structural Purity Group, Cancer and Infection Chemistry, AztraZeneca, Alderley Edge UK. Now works for Campden & Chorleywood Food Research Association Group, Gloucestershire.

2003-2007       Dr Anthony Ball (BSc, Chemistry UMIST) “Biotransformations in hydrofluorocarbon solvents.” Anthony is a drug/process development chemist for Shasun Pharma Solutions Ltd., Northumberland.

2003-2007        Professor B. Amir-heidari  (Iran) “Synthetic studies related to the biosynthesis of acidic lipopeptide antibiotics.” Runner up final year PhD presentation-awards. Amir is now a Assistant Professor and Dean of the Faculty of Pharmacy, Kerman University of Medical Sciences, Iran.

2002–2006      Dr Adam P. O’Rourke (MChem and MPhil by research Chemistry) “Solid phase synthesis and nucleic acid binding properties of mixed sequence pyrrolidine-amide oligonucleotide mimics” Adam is a research chemist at FujiFilm in Blackley.

2002–2006      Dr Raymond Wong (MChem, UMIST) “Dynamic-combinatorial approaches towards the non-enzymatic transcription of nucleic acids.” Ray completed a one year PDRA position in the JM lab and now works for Phenomenex.

2002–2006      Dr Lee Jon Ball (MChem, UMIST) “NMR structural studies of acidic lipopeptide antibiotics.”

2000–2004      Dr Claire Milne (BSc, Chemistry, University of Abertay). “Combinatorial biosynthesis of lipopeptide antibiotics: Mode of biosynthesis and mutasynthesis studies.” Claire won the prize for the best lecture at the RSC National Bio-organic Group Postgraduate Symposium 2003 and the Greater Manchester Symposium 2003. Claire was also the winner of the departmental final year prize and is now working for Astra Zeneca R&D Mölndal, Sweden (Biotransformations Team Leader).

2000–2004      Dr Simon Saul  (BSc, Chemistry, John Moores University, Liverpool). “Biotransformations in HFC solvents.” Simon is now a research scientist in the US oil & chemical technology company Baker Petrolite in Liverpool.

2000–2004      Dr Mathew Borg (Biological Sci, Malta), “Engineered biosynthesis of novel lipopeptide antibiotics: The enzymes involved in synthesis of the 2,3-epoxyhexanoyl fatty acid side chain ” Matt works for the biotechnology start-up company Recombinogen based at Guildford in Surrey.

2000-2005†     Dr Anila Khan  (BSc Chemistry & MSc University of Huddersfield), “The second generation of pyrrolidine amide oligonucleotide mimics.” Anila’s first  position was as a medicinal chemist at Aztra Zeneca Alderley Edge. Anila now works for Thermofisher in Runcorn, as an analytical chemist.

2000–2005      Dr Lyndsey Gordon (BSc, Biomolecular Science, UMIST), “Engineered biosynthesis of novel lipopeptide antibiotics: 3-Hydroxyasparagine phosphotransferase and NRPS Ad-domain specificities.” Certified medical illness prevented completion within 4 years (JM co-supervisor, registered in BMS).

1999–2003      Dr Samuel T. H. Tan (Singapore, BSc Chemistry UMIST), “Synthesis and Biophysical studies of pyrrolidine–amide oligonucleotide mimics (POM).” Sam was employed by the US biotech company Galileo Pharma in Singapore and now works for GSK Global Manufacturing and Supply in Singapore. Sam won the prize for best poster at the RSC National Bio-organic Group Postgraduate Symposium, John Innes Centre, Norwich, 17 Dec 2001 and was the winner of the departmental final year prize. Sam was also second at the Greater Manchester Symposium.

1999–2003      Dr Joanne M. Neary (BSc & MPhil Biological Science, University of Manchester), “The function of the Non–ribosomal peptide synthetases and other key enzymes in CDA lipopeptide antibiotic biosynthesis.” Joanne has a research position in a biotechnology start-up company Recombinogen based at Guildford in Surrey.

1996–2000      Dr David T. Hickman (Chemistry, University of Glasgow) “Pyrrolidine-amide oligonucleotide mimics (POM).” David was a Marie Curie Fellow at the Université Louis Pasteur (France) working with Prof. Jean-Marie Lehn (Nobel Laureate) and is now employed by the biotechnology company AC Immune (JM Lehn Chairman) Lausanne, Switzerland.

1995–1999      Dr Kevin J. Fettes (Chemistry, University of Dundee), “Synthesis of 3´-N-sulfamate and sulfamide modified oligonucleotides.” Kevin became a temporary Lecturer in Organic Chemistry at the University of Newcastle, after postdoctoral work at the University of Liverpool with Dr R. Cosstick and Prof S. Roberts. He now works for Avecia (Biotech.) Boston USA, having initially worked for Avecia (Grangemouth, Scotland) on the production of modified oligonucleotide therapeutics.

†2001              Richard Hamilton (MChem, UMIST), “Synthesis and nucleic acid binding properties of de novo zwitterionic pyrrolidine-phosphonate oligonucleotide mimics.”

†2007              Rebecca Carrey (MChem, Univ of Manchester).  “New methods for site specific protein immobilisation.”

Lab Technicians

2012-2013        Dr Jayendra Shankar

2010                  Dr Majid Al Nakeeb

2007-2009     Sr Sri Anendya Lestari

 


Comments are closed.